« MediaWiki:Common.js » : différence entre les versions

Dernière version du 9 mars 2026 à 22:21

// Forcer l'ouverture des sections hidden dans citizen qui les cachent par défaut

function ouvrirSections() {
    document.querySelectorAll('.citizen-section').forEach(function (el) {
        el.removeAttribute('hidden');
    });
}

document.addEventListener('DOMContentLoaded', ouvrirSections);

window.addEventListener('pageshow', function (e) {
    if (e.persisted) {
        ouvrirSections();
    }
});

new MutationObserver(ouvrirSections).observe(document.documentElement, { childList: true, subtree: true });
// ============================================
// CALCULATEUR IRC — Microguide
// ============================================
if (mw.config.get('wgPageName') === 'Calculateur') {

    var style = document.createElement('style');
    style.textContent = `
        #calc-app * { box-sizing: border-box; font-family: 'Segoe UI', system-ui, sans-serif; }
        #calc-app { background: #f0f4f8; padding: 16px; border-radius: 12px; }
        .calc-header { background: linear-gradient(135deg, #1a5fa8 0%, #2980d4 100%); padding: 18px 22px; border-radius: 12px; color: white; margin-bottom: 16px; }
        .calc-header h1 { margin: 0; font-size: 20px; font-weight: 700; }
        .calc-header p { margin: 4px 0 0; font-size: 12px; opacity: 0.75; }
        .calc-card { background: white; border-radius: 12px; padding: 20px 22px; margin-bottom: 14px; box-shadow: 0 2px 8px rgba(0,0,0,0.06); border: 1px solid #e2e8f0; }
        .calc-card h2 { margin: 0 0 14px; font-size: 15px; font-weight: 700; color: #0f2d5e; }
        .calc-grid { display: grid; grid-template-columns: 1fr 1fr 1fr 1fr; gap: 10px; margin-bottom: 12px; }
        .calc-grid label { font-size: 11px; color: #64748b; font-weight: 600; display: block; margin-bottom: 4px; }
        .calc-grid input { width: 100%; padding: 8px 10px; border-radius: 8px; border: 1.5px solid #e2e8f0; font-size: 14px; color: #0f2d5e; font-weight: 600; outline: none; }
        .calc-sexe-btn { padding: 6px 18px; border-radius: 8px; border: 1.5px solid #e2e8f0; background: white; color: #64748b; font-weight: 600; cursor: pointer; font-size: 13px; margin-right: 8px; }
        .calc-sexe-btn.active { border-color: #0f2d5e; background: #0f2d5e; color: white; }
        .calc-result-box { background: #f8fafc; border-radius: 10px; padding: 14px 18px; display: flex; align-items: center; gap: 20px; flex-wrap: wrap; margin-top: 10px; }
        .calc-clcr-val { font-size: 32px; font-weight: 800; line-height: 1; }
        .calc-clcr-label { font-size: 12px; font-weight: 600; margin-top: 2px; }
        .calc-search { width: 100%; padding: 10px 14px; border-radius: 10px; border: 1.5px solid #e2e8f0; font-size: 14px; margin-bottom: 10px; outline: none; }
        .calc-cats { display: flex; flex-wrap: wrap; gap: 8px; margin-bottom: 10px; }
        .calc-cat-btn { padding: 6px 14px; border-radius: 20px; border: 1.5px solid #e2e8f0; background: white; color: #475569; font-weight: 600; cursor: pointer; font-size: 12px; }
        .calc-cat-btn.active { border-color: #0f2d5e; background: #0f2d5e; color: white; }
        .calc-drugs { display: flex; flex-wrap: wrap; gap: 6px; margin-top: 8px; }
        .calc-drug-btn { padding: 6px 12px; border-radius: 8px; border: 1.5px solid #e2e8f0; background: white; color: #475569; font-weight: 500; cursor: pointer; font-size: 12px; }
        .calc-drug-btn.active { border-color: #1a9d8f; background: #e8f6f4; color: #0f7a6e; font-weight: 700; }
        .calc-table { width: 100%; border-collapse: collapse; font-size: 13px; margin-top: 10px; }
        .calc-table th { background: #f1f5f9; padding: 8px 12px; text-align: left; font-weight: 700; color: #0f2d5e; }
        .calc-table td { padding: 10px 12px; border-bottom: 1px solid #f1f5f9; }
        .calc-table tr.active-row { background: #e8f4f0 !important; outline: 2px solid #1a9d8f; }
        .calc-table tr.active-row td { color: #0a5a52; font-weight: 700; }
        .calc-badge { background: #1a9d8f; color: white; font-size: 10px; padding: 2px 6px; border-radius: 4px; margin-left: 8px; font-weight: 700; }
        .calc-note { background: #fefce8; border: 1px solid #fde68a; border-radius: 8px; padding: 10px 14px; font-size: 12px; color: #92400e; margin-bottom: 12px; }
        .calc-warning { background: #fef2f2; border: 1px solid #fecaca; border-radius: 10px; padding: 12px 16px; font-size: 11px; color: #991b1b; margin-top: 14px; }
        .calc-search-results button { display: block; width: 100%; text-align: left; padding: 8px 12px; margin-bottom: 4px; background: #f8fafc; border: 1px solid #e2e8f0; border-radius: 8px; cursor: pointer; font-size: 13px; color: #0f2d5e; }
        .calc-hint { margin-top: 12px; padding: 10px 14px; background: #f0f9ff; border-radius: 8px; font-size: 12px; color: #0369a1; }
        .calc-imc-info { border-left: 1px solid #e2e8f0; padding-left: 16px; font-size: 11px; color: #d97706; }
        @media (max-width: 600px) { .calc-grid { grid-template-columns: 1fr 1fr; } }
    `;
    document.head.appendChild(style);

    var ANTIBIOS = {
        "Céphalosporines": {
            "Céfadroxil (PO)": { notes: "", doses: [
                { min: 30, max: 999, label: "500 mg PO q12h ou 1g PO q12-24h" },
                { min: 20, max: 29, label: "1g PO x1 dose puis 500 mg PO q12h" },
                { min: 10, max: 19, label: "1g PO x1 dose puis 500 mg PO q24h" },
                { min: 0, max: 9, label: "1g PO x1 dose puis 500 mg PO q24-36h" },
            ]},
            "Céfazoline (IV)": { notes: "", doses: [
                { min: 35, max: 999, label: "1-2g IV q8h (fréq. max. q6h)" },
                { min: 11, max: 34, label: "1-2g IV q12h" },
                { min: 0, max: 10, label: "1g IV q24h" },
            ]},
            "Céfépime (IV) — IIA/IU": { notes: "Infections intra-abdominales et urinaires", doses: [
                { min: 30, max: 999, label: "1-2g IV q12h" },
                { min: 11, max: 29, label: "1-2g IV q24h" },
                { min: 6, max: 10, label: "1g IV q24h" },
                { min: 0, max: 5, label: "500 mg IV q24h" },
            ]},
            "Céfépime (IV) — NF": { notes: "Neutropénie fébrile", doses: [
                { min: 30, max: 999, label: "2g IV q8h" },
                { min: 11, max: 29, label: "2g IV q12h" },
                { min: 6, max: 10, label: "2g IV q24h" },
                { min: 0, max: 5, label: "1g IV q24h" },
            ]},
            "Céfixime (PO)": { notes: "", doses: [
                { min: 21, max: 999, label: "400 mg PO q24h" },
                { min: 11, max: 20, label: "300 mg (¾ co.) PO q24h" },
                { min: 0, max: 10, label: "200 mg PO q24h" },
            ]},
            "Céfotaxime (IV)": { notes: "", doses: [
                { min: 21, max: 999, label: "1-2g IV q6-8h (jusqu'à 2g IV q4h si SNC)" },
                { min: 0, max: 20, label: "Diminuer la dose de 50%. Certains: 2g IV q12-24h" },
            ]},
            "Céfoxitine (IV)": { notes: "Dose max: 12g/jour", doses: [
                { min: 30, max: 999, label: "1-2g IV q6-8h" },
                { min: 11, max: 29, label: "1-2g IV q8-12h" },
                { min: 5, max: 10, label: "1-2g IV q12-24h" },
                { min: 1, max: 4, label: "50% de la dose IV q12-24h" },
                { min: 0, max: 0, label: "50% de la dose IV q24-48h" },
            ]},
            "Cefprozil (PO)": { notes: "", doses: [
                { min: 31, max: 999, label: "250-500 mg PO q12h" },
                { min: 0, max: 30, label: "250 mg PO q12h" },
            ]},
            "Ceftazidime (IV)": { notes: "", doses: [
                { min: 31, max: 999, label: "1-2g IV q8h" },
                { min: 16, max: 30, label: "1-2g IV q12h" },
                { min: 6, max: 15, label: "1-2g IV q24h" },
                { min: 1, max: 5, label: "500mg-1g IV q24h" },
                { min: 0, max: 0, label: "500mg-1g IV q48h" },
            ]},
            "Ceftobiprole (IV)": { notes: "Perfusion sur 4h si Clcr > 150 mL/min", doses: [
                { min: 31, max: 999, label: "500 mg IV q8h perf. sur 2h" },
                { min: 16, max: 30, label: "500 mg IV q12h perf. sur 2h" },
                { min: 6, max: 15, label: "250 mg IV q12h perf. sur 2h" },
                { min: 0, max: 5, label: "250 mg IV q24h perf. sur 2h" },
            ]},
            "Ceftriaxone (IV)": { notes: "Aucun ajustement requis sauf IR + IH (dose max: 2g/jour)", doses: [
                { min: 0, max: 999, label: "1-2g IV q24h (max: 2g IV q12h pour SNC)" },
            ]},
            "Céfuroxime axétil (PO)": { notes: "", doses: [
                { min: 11, max: 999, label: "250-500 mg PO q12h" },
                { min: 0, max: 10, label: "250 mg PO q24h" },
            ]},
            "Céfuroxime (IV)": { notes: "", doses: [
                { min: 21, max: 999, label: "750mg-1,5g IV q8h" },
                { min: 11, max: 20, label: "750 mg IV q12h" },
                { min: 0, max: 10, label: "750 mg IV q24h" },
            ]},
            "Céphalexine (PO)": { notes: "", doses: [
                { min: 41, max: 999, label: "250mg-1g PO q6h" },
                { min: 11, max: 40, label: "250-500 mg PO q8-12h" },
                { min: 0, max: 10, label: "250-500 mg PO q12-24h" },
            ]},
        },
        "Carbapénèmes": {
            "Ertapénem (IV)": { notes: "", doses: [
                { min: 31, max: 999, label: "1g IV q24h" },
                { min: 0, max: 30, label: "500 mg IV q24h" },
            ]},
            "Imipénem-Cilastatine (IV)": { notes: "PR ≥ 70 kg: 500 mg IV q6h (max 4g/jour). PR < 70 kg: voir monographie.", doses: [
                { min: 71, max: 999, label: "500 mg IV q6h (max: 4g/jour)" },
                { min: 41, max: 70, label: "500 mg IV q6-8h" },
                { min: 21, max: 40, label: "500 mg IV q8-12h" },
                { min: 6, max: 20, label: "250 mg IV q12h" },
                { min: 0, max: 5, label: "⚠️ Non recommandé" },
            ]},
            "Méropénem (IV) — usuel": { notes: "Posologie usuelle", doses: [
                { min: 26, max: 999, label: "1g IV q8h" },
                { min: 11, max: 25, label: "1g IV q12h" },
                { min: 6, max: 10, label: "500 mg IV q12h" },
                { min: 0, max: 5, label: "500 mg IV q24h" },
            ]},
            "Méropénem (IV) — SNC": { notes: "Infections du SNC", doses: [
                { min: 26, max: 999, label: "2g IV q8h" },
                { min: 11, max: 25, label: "2g IV q12h" },
                { min: 6, max: 10, label: "1g IV q12h" },
                { min: 0, max: 5, label: "1g IV q24h" },
            ]},
        },
        "Macrolides": {
            "Azithromycine (PO)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "250-500 mg PO q24h" }]},
            "Azithromycine (IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "500 mg IV q24h" }]},
            "Clarithromycine (PO)": { notes: "", doses: [
                { min: 31, max: 999, label: "250-500 mg PO q12h" },
                { min: 0, max: 30, label: "250 mg PO q24h (ou q12h si infection sévère)" },
            ]},
            "Érythromycine (PO/IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "Posologie selon indication et formulation" }]},
        },
        "Pénicillines": {
            "Amoxicilline (PO)": { notes: "", doses: [
                { min: 31, max: 999, label: "250mg-1g PO q8h" },
                { min: 11, max: 30, label: "250-500 mg PO q12h" },
                { min: 0, max: 10, label: "250-500 mg PO q24h" },
            ]},
            "Amoxicilline-Clavulanate (PO)": { notes: "", doses: [
                { min: 31, max: 999, label: "500/125 mg PO q8h ou 875/125 mg PO q12h" },
                { min: 11, max: 30, label: "500/125 mg PO q12h" },
                { min: 0, max: 10, label: "500/125 mg PO q24h" },
            ]},
            "Ampicilline (IV)": { notes: "Posologie usuelle: 1-2g IV q4-6h", doses: [
                { min: 41, max: 999, label: "1-2g IV q6h" },
                { min: 31, max: 40, label: "1-2g IV q6-8h" },
                { min: 16, max: 30, label: "1-2g IV q8-12h" },
                { min: 0, max: 15, label: "1-2g IV q12-24h" },
            ]},
            "Cloxacilline (PO)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "250-500 mg PO q6h (jusqu'à 4g/jour)" }]},
            "Cloxacilline (IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "1-2g IV q4-6h" }]},
            "Pénicilline G sodique (IV)": { notes: "DC = dose de charge", doses: [
                { min: 21, max: 999, label: "1-4 mU IV q4-6h" },
                { min: 11, max: 20, label: "DC suivie de 50% de la dose IV q4-6h" },
                { min: 0, max: 10, label: "DC suivie de 50% de la dose IV q8-12h" },
            ]},
            "Pipéracilline-Tazobactam (IV) — usuel": { notes: "Posologie usuelle", doses: [
                { min: 41, max: 999, label: "3,375g [3g/0,375g] IV q6h ou 4,5g [4g/0,5g] IV q8h" },
                { min: 21, max: 40, label: "2,25g [2g/0,25g] IV q6h" },
                { min: 0, max: 20, label: "2,25g [2g/0,25g] IV q8h" },
            ]},
            "Pipéracilline-Tazobactam (IV) — PAH/NF": { notes: "Pneumonie hospitalière ou neutropénie fébrile", doses: [
                { min: 41, max: 999, label: "4,5g [4g/0,5g] IV q6h" },
                { min: 21, max: 40, label: "3,375g [3g/0,375g] IV q6h" },
                { min: 0, max: 20, label: "2,25g [2g/0,25g] IV q6h" },
            ]},
        },
        "Fluoroquinolones": {
            "Ciprofloxacine (PO)": { notes: "", doses: [
                { min: 31, max: 999, label: "500-750 mg PO q12h" },
                { min: 16, max: 30, label: "500 mg PO q12h" },
                { min: 0, max: 15, label: "500 mg PO q24h ou 250 mg PO q12h" },
            ]},
            "Ciprofloxacine (IV)": { notes: "", doses: [
                { min: 31, max: 999, label: "400 mg IV q8-12h" },
                { min: 16, max: 30, label: "400 mg IV q12h" },
                { min: 0, max: 15, label: "400 mg IV q24h ou 200 mg IV q12h" },
            ]},
            "Lévofloxacine — légère/prostatite": { notes: "Ex: prostatite chronique", doses: [
                { min: 51, max: 999, label: "500 mg PO/IV q24h" },
                { min: 21, max: 50, label: "500 mg PO/IV x1 dose, puis 250 mg PO/IV q24h" },
                { min: 0, max: 20, label: "500 mg PO/IV x1 dose, puis 250 mg PO/IV q48h" },
            ]},
            "Lévofloxacine — PAH": { notes: "Pneumonie hospitalière", doses: [
                { min: 51, max: 999, label: "750 mg PO/IV q24h" },
                { min: 21, max: 50, label: "750 mg PO/IV q48h" },
                { min: 0, max: 20, label: "750 mg PO/IV x1 dose, puis 500 mg PO/IV q48h" },
            ]},
            "Moxifloxacine (PO/IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "400 mg PO/IV q24h" }]},
            "Norfloxacine (PO) — IU": { notes: "Infection urinaire", doses: [
                { min: 31, max: 999, label: "400 mg PO q12-24h" },
                { min: 0, max: 30, label: "400 mg PO q24h" },
            ]},
        },
        "Autres antibactériens": {
            "Clindamycine (PO)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "150-450 mg PO q6h" }]},
            "Clindamycine (IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "600-900 mg IV q8h (fréq. max.: q6h)" }]},
            "Daptomycine (IV) — usuelle": { notes: "Pour dose 6 mg/kg: utiliser PD si PR > 140 kg", doses: [
                { min: 31, max: 999, label: "4-6 mg/kg PR IV q24h" },
                { min: 0, max: 30, label: "Même dose IV q48h" },
            ]},
            "Doxycycline (PO)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "100 mg PO q12h" }]},
            "Linézolide (PO/IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "600 mg PO/IV q12h" }]},
            "Métronidazole (PO)": { notes: "", doses: [
                { min: 11, max: 999, label: "250-500 mg PO q8h ou 500 mg PO q12h" },
                { min: 0, max: 10, label: "500 mg PO q12h" },
            ]},
            "Métronidazole (IV)": { notes: "", doses: [
                { min: 11, max: 999, label: "500 mg IV q8h (fréq. max.: q6h)" },
                { min: 0, max: 10, label: "500 mg IV q12h" },
            ]},
            "Nitrofurantoïne (PO)": { notes: "Cystite non compliquée uniquement", doses: [
                { min: 46, max: 999, label: "50-100 mg PO QID ou 100 mg PO q12h (monohydrate)" },
                { min: 31, max: 45, label: "Données limitées. Possiblement efficace à court terme." },
                { min: 0, max: 30, label: "⚠️ Contre-indiqué — risque de toxicité accru" },
            ]},
            "Tétracycline (PO)": { notes: "", doses: [
                { min: 51, max: 999, label: "250-500 mg PO q6h" },
                { min: 11, max: 50, label: "250-500 mg PO q12h" },
                { min: 0, max: 10, label: "250-500 mg PO q24h" },
            ]},
            "Tigécycline (IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "100 mg IV x1 dose puis 50 mg IV q12h" }]},
            "Triméthoprime (PO)": { notes: "", doses: [
                { min: 16, max: 999, label: "100 mg PO q12h" },
                { min: 6, max: 15, label: "50 mg PO q12h" },
                { min: 0, max: 5, label: "⚠️ Non recommandé" },
            ]},
            "TMP-SMX — usuel": { notes: "80 mg TMP = 1 co SS; 160 mg TMP = 1 co DS", doses: [
                { min: 31, max: 999, label: "160-320 mg TMP PO/IV q12h" },
                { min: 16, max: 30, label: "80 mg TMP PO/IV q12h ou 160 mg TMP PO/IV q24h" },
                { min: 0, max: 15, label: "⚠️ Non recommandé" },
            ]},
            "Vancomycine (IV)": { notes: "⚠️ Amorcer empiriquement selon âge, fonction rénale et poids puis ajuster selon dosages sériques. DC = 25 mg/kg PR. DM: 15-20 mg/kg PD/dose q8-12h (max 2g/dose). Consulter pharmacien.", doses: [
                { min: 71, max: 999, label: "DM IV q12h — surveiller dosages sériques" },
                { min: 41, max: 70, label: "DM IV q24h — surveiller dosages sériques" },
                { min: 21, max: 40, label: "DM IV q36-48h — dosages sériques quotidiens" },
                { min: 11, max: 20, label: "DM IV q72-96h" },
                { min: 0, max: 10, label: "DM IV q5-7 jours — consulter pharmacien" },
            ]},
            "Vancomycine (PO)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "125 mg PO QID (max 500 mg PO QID si infection compliquée)" }]},
        },
        "Antifongiques": {
            "Anidulafungine (IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "200 mg IV x1 dose puis 100 mg IV q24h" }]},
            "Caspofungine (IV)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "70 mg IV x1 dose puis 50 mg IV q24h" }]},
            "Fluconazole (PO/IV)": { notes: "DC = 100% de la dose. Écart: 100-800 mg PO/IV q24h", doses: [
                { min: 51, max: 999, label: "DC puis 100% dose PO/IV q24h" },
                { min: 11, max: 50, label: "DC puis 50% de la dose PO/IV q24h" },
                { min: 0, max: 10, label: "DC puis 25-50% de la dose PO/IV q24h" },
            ]},
            "Isavuconazole (PO/IV)": { notes: "Aucun ajustement requis. 372 mg sulfate = 200 mg isavuconazole.", doses: [{ min: 0, max: 999, label: "DC: 200 mg PO/IV q8h x6 doses, puis 200 mg PO/IV q24h" }]},
            "Kétoconazole (PO)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "200-400 mg PO q24h" }]},
            "Micafungine — prophylaxie": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "50-100 mg IV q24h" }]},
            "Micafungine — traitement": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "100-150 mg IV q24h" }]},
            "Terbinafine (PO)": { notes: "", doses: [
                { min: 51, max: 999, label: "250 mg PO q24h" },
                { min: 0, max: 50, label: "⚠️ Non recommandé — données limitées" },
            ]},
        },
        "Antimycobactériens": {
            "Ethambutol (PO)": { notes: "Si PR > 120% PI, baser dose sur PI.", doses: [
                { min: 31, max: 999, label: "15-25 mg/kg PO q24h" },
                { min: 0, max: 30, label: "15-25 mg/kg/dose PO DIE 3 jours/semaine" },
            ]},
            "Isoniazide (PO)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "5 mg/kg PO q24h (max: 300 mg)" }]},
            "Pyrazinamide (PO)": { notes: "Si PR > 120% PI, baser dose sur PI.", doses: [
                { min: 31, max: 999, label: "20-25 mg/kg PO q24h (max: 2g)" },
                { min: 0, max: 30, label: "25-35 mg/kg/dose PO DIE 3 jours/semaine" },
            ]},
            "Rifabutine (PO)": { notes: "", doses: [
                { min: 16, max: 999, label: "300 mg PO q24h" },
                { min: 0, max: 15, label: "150 mg PO q24h" },
            ]},
            "Rifampicine (PO)": { notes: "Aucun ajustement requis", doses: [{ min: 0, max: 999, label: "10 mg/kg PO q24h (max: 600 mg)" }]},
        },
        "Antiviraux": {
            "Acyclovir (IV)": { notes: "Posologie usuelle: 5-15 mg/kg/dose IV q8h", doses: [
                { min: 26, max: 999, label: "100% de la dose IV q8h" },
                { min: 11, max: 25, label: "100% de la dose IV q12h" },
                { min: 6, max: 10, label: "100% de la dose IV q24h" },
                { min: 0, max: 5, label: "50% de la dose IV q24h" },
            ]},
            "Acyclovir (PO) — zona": { notes: "", doses: [
                { min: 26, max: 999, label: "800 mg PO q4h (5 fois/jour)" },
                { min: 11, max: 25, label: "800 mg PO q8h" },
                { min: 0, max: 10, label: "800 mg PO q12h" },
            ]},
            "Famciclovir (PO) — zona": { notes: "", doses: [
                { min: 41, max: 999, label: "500 mg PO q8h" },
                { min: 21, max: 40, label: "500 mg PO q12h" },
                { min: 6, max: 20, label: "500 mg PO q24h" },
                { min: 0, max: 5, label: "250 mg PO q24h" },
            ]},
            "Oseltamivir (PO) — traitement": { notes: "Influenza A et B", doses: [
                { min: 31, max: 999, label: "75 mg PO q12h" },
                { min: 11, max: 30, label: "30 mg PO q12h" },
                { min: 6, max: 10, label: "30 mg PO q24h" },
                { min: 0, max: 5, label: "75 mg PO x1 dose" },
            ]},
            "Oseltamivir (PO) — prophylaxie": { notes: "Prophylaxie Influenza A et B", doses: [
                { min: 31, max: 999, label: "75 mg PO q24h" },
                { min: 11, max: 30, label: "30 mg PO q24h" },
                { min: 6, max: 10, label: "30 mg PO q48h" },
                { min: 0, max: 5, label: "Privilégier zanamivir inhalation" },
            ]},
            "Valacyclovir (PO) — zona": { notes: "", doses: [
                { min: 31, max: 999, label: "1g PO q8h" },
                { min: 16, max: 30, label: "1g PO q12h" },
                { min: 6, max: 15, label: "1g PO q24h" },
                { min: 0, max: 5, label: "500 mg PO q24h" },
            ]},
            "Valacyclovir (PO) — herpès génital": { notes: "", doses: [
                { min: 31, max: 999, label: "1g PO q12h" },
                { min: 16, max: 30, label: "1g PO q24h" },
                { min: 0, max: 15, label: "500 mg PO q24h" },
            ]},
        },
    };

    function calcClcr(age, poids, creat, sexe) {
        var k = sexe === 'F' ? 0.85 : 1.0;
        return ((140 - age) * poids / (49 * creat)) * 60 * k;
    }
    function calcPI(taille, sexe) {
        return sexe === 'F' ? 45.5 + 0.91 * (taille - 152) : 50 + 0.91 * (taille - 152);
    }
    function calcIMC(poids, taille) {
        return poids / Math.pow(taille / 100, 2);
    }

    var state = {
        age: '', poids: '', taille: '', creat: '', sexe: 'H',
        selectedCat: '', selectedDrug: '', search: '',
        mode: 'cg', dfgDirect: ''
    };

    function getDrugData(cat, drug) {
        return ANTIBIOS[cat] && ANTIBIOS[cat][drug] ? ANTIBIOS[cat][drug] : null;
    }

    function getActiveDose(doses, clcr) {
        var clcrRounded = Math.round(clcr * 10) / 10;
        for (var i = 0; i < doses.length; i++) {
            if (clcrRounded >= doses[i].min && clcrRounded <= doses[i].max) return i;
        }
        for (var i = doses.length - 1; i >= 0; i--) {
            if (clcrRounded >= doses[i].min) return i;
        }
        return doses.length - 1;
    }

    function calcClcrFromState() {
        if (state.mode === 'direct') {
            var dfg = parseFloat(state.dfgDirect);
            return { clcr: isNaN(dfg) ? null : dfg, imc: null, pi: null, poidsCalc: null };
        }
        var age = parseFloat(state.age);
        var poids = parseFloat(state.poids);
        var taille = parseFloat(state.taille);
        var creat = parseFloat(state.creat);
        var imc = (!isNaN(poids) && !isNaN(taille)) ? calcIMC(poids, taille) : null;
        var pi = (!isNaN(taille)) ? calcPI(taille, state.sexe) : null;
        var poidsCalc = null;
        if (!isNaN(poids) && !isNaN(taille)) {
            poidsCalc = imc < 30 ? poids : pi + 0.4 * (poids - pi);
        }
        var clcr = (!isNaN(age) && poidsCalc !== null && !isNaN(creat)) ? calcClcr(age, poidsCalc, creat, state.sexe) : null;
        return { clcr: clcr, imc: imc, pi: pi, poidsCalc: poidsCalc };
    }

    function renderResult() {
        var res = calcClcrFromState();
        var clcr = res.clcr; var imc = res.imc; var pi = res.pi; var poidsCalc = res.poidsCalc;

        var clcrColor = '#64748b'; var clcrLabel = '';
        if (clcr !== null) {
            if (clcr >= 60) { clcrColor = '#16a34a'; clcrLabel = 'Normale / légèrement réduite'; }
            else if (clcr >= 30) { clcrColor = '#d97706'; clcrLabel = 'IRC modérée'; }
            else if (clcr >= 15) { clcrColor = '#ea580c'; clcrLabel = 'IRC sévère'; }
            else { clcrColor = '#dc2626'; clcrLabel = 'IRC très sévère / terminale'; }
        }

        // Update ClCr result box
        var box = document.getElementById('calc-result-box');
        if (box) {
            if (clcr !== null) {
                var html = '<div>';
                html += '<div style="font-size:11px;color:#64748b;font-weight:600">' + (state.mode === 'direct' ? 'DFG (LABORATOIRE)' : 'CLAIRANCE CRÉATININE') + '</div>';
                html += '<div class="calc-clcr-val" style="color:' + clcrColor + '">' + clcr.toFixed(1) + ' <span style="font-size:14px;font-weight:500">mL/min</span></div>';
                html += '<div class="calc-clcr-label" style="color:' + clcrColor + '">' + clcrLabel + '</div>';
                html += '</div>';
                if (imc !== null) {
                    html += '<div class="calc-imc-info">';
                    html += '<div style="font-size:11px;color:#64748b;font-weight:600">IMC</div>';
                    html += '<div style="font-size:20px;font-weight:700;color:#0f2d5e">' + imc.toFixed(1) + ' <span style="font-size:11px">kg/m²</span></div>';
                    if (imc >= 30 && pi) {
                        html += '<div>IMC ≥ 30 — Poids de dosage: <b>' + poidsCalc.toFixed(1) + ' kg</b><br>Poids idéal: ' + pi.toFixed(1) + ' kg</div>';
                    }
                    html += '</div>';
                }
                box.innerHTML = html;
                box.style.display = 'flex';
                box.style.border = '2px solid ' + clcrColor + '33';
            } else {
                box.innerHTML = '';
                box.style.display = 'none';
            }
        }

        // Update sexe buttons
        var btnH = document.getElementById('calc-btn-h');
        var btnF = document.getElementById('calc-btn-f');
        if (btnH) btnH.className = 'calc-sexe-btn' + (state.sexe === 'H' ? ' active' : '');
        if (btnF) btnF.className = 'calc-sexe-btn' + (state.sexe === 'F' ? ' active' : '');

        // Update drug result
        renderDrugResult(clcr);
    }

    function renderDrugResult(clcr) {
        var drugData = getDrugData(state.selectedCat, state.selectedDrug);
        var section = document.getElementById('calc-drug-result');
        if (!section) return;

        if (!state.selectedDrug || !drugData) { section.innerHTML = ''; return; }

        var html = '<div class="calc-card">';
        html += '<h2>3. Posologie recommandée</h2>';
        html += '<div style="font-size:13px;color:#64748b;margin-bottom:14px">' + state.selectedDrug + '</div>';
        if (drugData.notes) html += '<div class="calc-note">⚠️ ' + drugData.notes + '</div>';
        html += '<table class="calc-table"><thead><tr><th>ClCr (mL/min)</th><th>Posologie</th></tr></thead><tbody>';
        var activeIdx = clcr !== null ? getActiveDose(drugData.doses, clcr) : -1;
        drugData.doses.forEach(function(d, i) {
            var isActive = clcr !== null && i === activeIdx;
            var rangeLabel = d.max >= 999 ? '≥ ' + d.min : d.min === 0 ? '< ' + (drugData.doses.filter(function(x){return x.min>0;}).map(function(x){return x.min;}).sort(function(a,b){return a-b;})[0]||5) : d.min + ' – ' + d.max;
            html += '<tr' + (isActive ? ' class="active-row"' : ' style="background:' + (i%2===0?'white':'#f8fafc') + '"') + '>';
            html += '<td style="font-weight:600;white-space:nowrap">' + (isActive ? '▶ ' : '') + rangeLabel + '</td>';
            html += '<td>' + d.label + (isActive ? '<span class="calc-badge">VOTRE PATIENT</span>' : '') + '</td>';
            html += '</tr>';
        });
        html += '</tbody></table>';
        if (clcr === null) html += '<div class="calc-hint">💡 Entrez les données du patient (étape 1) pour mettre en évidence la posologie appropriée.</div>';
        html += '</div>';
        section.innerHTML = html;
    }

    function renderDrugSelector() {
        var searchResults = [];
        if (state.search && state.search.length >= 2) {
            var q = state.search.toLowerCase();
            Object.keys(ANTIBIOS).forEach(function(cat) {
                Object.keys(ANTIBIOS[cat]).forEach(function(drug) {
                    if (drug.toLowerCase().indexOf(q) !== -1) searchResults.push({ cat: cat, drug: drug });
                });
            });
        }

        var sr = document.getElementById('calc-search-results');
        if (sr) {
            var html = '';
            searchResults.forEach(function(r) {
                html += '<button onclick="calcSelectDrug(\'' + r.cat.replace(/'/g, "\\'") + '\',\'' + r.drug.replace(/'/g, "\\'") + '\')">';
                html += '<span style="color:#64748b;font-size:11px">' + r.cat + ' / </span>' + r.drug + '</button>';
            });
            sr.innerHTML = html;
        }

        var cats = document.getElementById('calc-cats');
        if (cats) {
            var html = '';
            Object.keys(ANTIBIOS).forEach(function(cat) {
                html += '<button class="calc-cat-btn ' + (state.selectedCat === cat ? 'active' : '') + '" onclick="calcSetCat(\'' + cat.replace(/'/g, "\\'") + '\')">' + cat + '</button>';
            });
            cats.innerHTML = html;
        }

        var drugs = document.getElementById('calc-drugs');
        if (drugs) {
            var html = '';
            if (state.selectedCat && ANTIBIOS[state.selectedCat]) {
                Object.keys(ANTIBIOS[state.selectedCat]).forEach(function(drug) {
                    html += '<button class="calc-drug-btn ' + (state.selectedDrug === drug ? 'active' : '') + '" onclick="calcSetDrug(\'' + drug.replace(/'/g, "\\'") + '\')">' + drug + '</button>';
                });
            }
            drugs.innerHTML = html;
        }
    }

    function render() {
        var app = document.getElementById('calc-app');
        if (!app) return;

        var html = '';
        html += '<div class="calc-header">';
        html += '<h1>Calculateur posologique — Insuffisance rénale</h1>';
        html += '<p>Basé sur le guide APES (RPEI) — Octobre 2019 • Adultes seulement • Le jugement clinique doit prévaloir</p>';
        html += '</div>';

        html += '<div class="calc-card">';
        html += '<h2>1. Fonction rénale</h2>';

        // Mode toggle
        html += '<div style="display:flex;gap:8px;margin-bottom:16px;">';
        html += '<button id="calc-btn-cg" class="calc-sexe-btn ' + (state.mode === 'cg' ? 'active' : '') + '" onclick="calcSetMode(\'cg\')">Calculer (Cockcroft-Gault)</button>';
        html += '<button id="calc-btn-direct" class="calc-sexe-btn ' + (state.mode === 'direct' ? 'active' : '') + '" onclick="calcSetMode(\'direct\')">DFG déjà connu</button>';
        html += '</div>';

        if (state.mode === 'cg') {
            html += '<div style="margin-bottom:12px;display:flex;align-items:center;gap:8px;">';
            html += '<span style="font-size:13px;color:#64748b;width:50px">Sexe</span>';
            html += '<button id="calc-btn-h" class="calc-sexe-btn ' + (state.sexe === 'H' ? 'active' : '') + '" onclick="calcSetSexe(\'H\')">Homme</button>';
            html += '<button id="calc-btn-f" class="calc-sexe-btn ' + (state.sexe === 'F' ? 'active' : '') + '" onclick="calcSetSexe(\'F\')">Femme</button>';
            html += '</div>';
            html += '<div class="calc-grid">';
            html += '<div><label>Âge (ans)</label><input id="calc-age" type="number" placeholder="ex: 65" oninput="calcSetField(\'age\',this.value)"></div>';
            html += '<div><label>Poids réel (kg)</label><input id="calc-poids" type="number" placeholder="ex: 70" oninput="calcSetField(\'poids\',this.value)"></div>';
            html += '<div><label>Taille (cm)</label><input id="calc-taille" type="number" placeholder="ex: 170" oninput="calcSetField(\'taille\',this.value)"></div>';
            html += '<div><label>Créatinine (μmol/L)</label><input id="calc-creat" type="number" placeholder="ex: 120" oninput="calcSetField(\'creat\',this.value)"></div>';
            html += '</div>';
        } else {
            html += '<div style="max-width:250px;">';
            html += '<label style="font-size:11px;color:#64748b;font-weight:600;display:block;margin-bottom:4px;">DFG / ClCr (mL/min)</label>';
            html += '<input id="calc-dfg-direct" type="number" placeholder="ex: 45" style="width:100%;padding:10px 14px;border-radius:8px;border:1.5px solid #e2e8f0;font-size:18px;font-weight:700;color:#0f2d5e;outline:none;" oninput="calcSetField(\'dfgDirect\',this.value)">';
            html += '<div style="font-size:11px;color:#64748b;margin-top:6px;">Valeur fournie par le laboratoire</div>';
            html += '</div>';
        }

        html += '<div id="calc-result-box" class="calc-result-box" style="display:none"></div>';
        html += '</div>';

        html += '<div class="calc-card">';
        html += '<h2>2. Sélection de l\'antimicrobien</h2>';
        html += '<input id="calc-search-input" class="calc-search" type="text" placeholder="🔍 Rechercher un antimicrobien..." oninput="calcSetSearch(this.value)">';
        html += '<div id="calc-search-results" class="calc-search-results"></div>';
        html += '<div id="calc-cats" class="calc-cats"></div>';
        html += '<div id="calc-drugs" class="calc-drugs"></div>';
        html += '</div>';

        html += '<div id="calc-drug-result"></div>';
        html += '<div class="calc-warning">⚠️ <b>Avertissement clinique :</b> Cet outil est basé sur le guide APES (RPEI, octobre 2019). Les ajustements servent uniquement à guider la décision clinique — le jugement clinique doit prévaloir. Consulter un pharmacien pour les cas complexes.</div>';

        app.innerHTML = html;
        renderResult();
        renderDrugSelector();
    }

    window.calcSetMode = function(mode) { state.mode = mode; render(); };
    window.calcSetField = function(field, val) {
        state[field] = val;
        renderResult();
    };
    window.calcSetSexe = function(sexe) { state.sexe = sexe; renderResult(); };
    window.calcSetSearch = function(val) { state.search = val; state.selectedCat = ''; state.selectedDrug = ''; renderDrugSelector(); renderDrugResult(calcClcrFromState().clcr); };
    window.calcSetCat = function(cat) { state.selectedCat = cat; state.selectedDrug = ''; renderDrugSelector(); renderDrugResult(calcClcrFromState().clcr); };
    window.calcSetDrug = function(drug) { state.selectedDrug = drug; renderDrugSelector(); renderDrugResult(calcClcrFromState().clcr); };
    window.calcSelectDrug = function(cat, drug) { state.selectedCat = cat; state.selectedDrug = drug; state.search = ''; var si = document.getElementById('calc-search-input'); if(si) si.value=''; renderDrugSelector(); renderDrugResult(calcClcrFromState().clcr); };

    if (document.readyState === 'loading') {
        document.addEventListener('DOMContentLoaded', render);
    } else {
        render();
    }
}